Neural Stem Cell Based-Oncolytic Virotherapy for Treatment of Glioblastoma
Time: 4:15 pm
day: Day Two
Details:
- Human neural stem cells are inherently tumor-tropic and can be modified to deliver a therapeutic agent
- Pre-clinical data show that neural stem cells can improve the distribution of an oncolytic virus by delivering it across normal brain tissue to multiple invasive tumor sites
- Neural stem cells can also protect the oncolytic virus from neutralizing antibodies while en route to sites of tumor
- A phase I study of multiple intracerebral doses of neural stem cells carrying a second generation conditionally replicative adenovirus is currently being conducted in patients with recurrent glioblastoma
