Triplet Therapy to Combat Pancreatic Cancer

Time: 10:30 am
day: Day Two


  • Pancreatic cancer has high stroma and myeloid cell content and has a dismal prognosis
  • LOAd703 is an adenovirus-based therapy encoding transgenes that target CD40 and 41BB in the tumor microenvironment (tumor and stroma) to generate anti-tumor immunity as well as replicating in cancer cells to cause oncolysis with release of antigens
  • LOAd703 is currently evaluated in combination with chemotherapy ± checkpoint blockade in patients with pancreatic cancer